Establishment of the Concept of Ion Channel

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Establishment of the Concept of Ion Channel Gate of Receptor Enzyme and Gas Enzyme of Receptor



Biochemical pharmacology is relatively aware of the existence of receptors and binding reactions with ligands. Of course, not all of the research findings.



But the function of the receptor itself as well as the function of enzymes and gas gates is completely unknown in biology.

In addition to the physiological conformation, the conformation changes produced by ligand binding to receptor are known in pharmacology.

There are also conformation formation and function of enzymes.



It is the energy released by the transition of orbital electrons in atoms or ions, which is the physical essence of the active action of various enzymes.

That is to say, in the ligand-receptor binding reaction, in addition to the formation of normal physiological conformation, there are other conformations that produce the formation of the structure of the active center of the enzyme.

The chemical groups in this structure image will attract gas enzymes. After electrostatic binding, the gas enzymes are decomposed and ionized by the energy of the active center, resulting in the ions of gas enzymes.

These ions then pass through the receptor's ion-related gates to gaseous enzymes and enter the cell.

The open formation of the gas-enzyme-related gates of receptors is also the channel gates formed by the conformational changes in the binding energy produced by the chemical bonds in the binding of ligands or gas enzymes to receptors.



It is now clear that the formation of the functional conformation of the receptor enzymes is related to the ligand-binding reaction. Without the precondition of the ligand-receptor binding reaction or the effect of the binding energy, the rotation of the chemical group in the receptor enzymes and the recombination of the electric field of other groups will not result in the formation of the active center of the receptor enzymes.

Furthermore, the binding of the enzyme with gaseous enzymes and the reaction of hydrolysis of gaseous enzymes will not be produced. Of course, the conformation of ion-related channel gates of gaseous enzymes can not be formed.

This is reflected in the pathological reaction.

For example, when the synthesis of thyroxine decreases, it is because the changes in the basic conformation of the thyroid receptor can not bind to the higher substance related to the synthesis of the hormone, and there is no release of the binding reaction energy of the chemical group. In addition to reducing the physiological concentration of thyroxine, the receptor is simply formed with the physiological conformation of the pharmacological understanding. Relevant receptors, but there is no formation of the active structure of enzymes, and gas enzymes can not react with thyroxine receptor enzymes and be hydrolyzed into ions by receptor enzymes, of course, gas enzymes ion channel gates can not be formed, the concentration of these gas enzymes will inevitably increase and diffuse!




It can be inferred that there are many receptor enzymes.



Receptor enzymes exist in the presence of ligand-receptor binding receptors.

Although some receptors of ligand substances are in the cell membrane, the ionization of these ligands should also be outside the cell membrane, and they must also have corresponding conformational changes in order to enter the cell. The energy source of the conformational changes of the cell membrane receptor is obtained from the energy release of the binding bond between the chemical group and the cell membrane receptor.

It is possible that the binding chemicals are ionized ligands, such as ionic substances of thyroxine.



When these ionized ligands bind to the receptor, the energy produced by the binding chemical bond changes the rotational conformation of the receptor group. These conformations not only have the physiological conformation or the formation of the channel gates known pharmacologically, but also form the active conformation of the cell membrane receptor into the enzyme, which is the formation of the active conformation or the active structure. It also attracts and hydrolyzes gaseous enzymes into ions, and can also form ion channel gates of gaseous enzymes.

If ionized ligands do not bind to receptors, membrane receptors will not become enzymatic substances.

Gas enzymes will not be hydrolyzed by cell membrane receptor enzymes, but will also be produced by intensive increase and diffusion!

The precondition is that the conformation of the cell membrane of these receptor ligand substances in cells should be normal. If the conformation changes without binding sites, gas diffusion will occur.

On Molecular Rotation Angle

The angle between different amino acid spirochetes or between spirochetes and peptides is related to the number of chemical bonds formed by weak electrostatic attraction or the degree of stability of the relationship between them.

The smaller the turning angle, the more bonds and the stronger the stability of the molecular bonds between spirochetes and peptides. On the contrary, the larger the turning angle, the less the number of molecular bonds formed, and the weaker the interaction between spirochetes and spirochetes.

However, if the number of stable bonds is large, they will not be decomposed when the electrical action of ligands or gaseous enzymes increases.

When the density of ligands or gaseous enzymes increases, they will be decomposed.

More importantly, the decomposition of these molecular bonds will further result in the vertical or non-vertical rotation of H groups related to amino acids in the helix of amino acids.

If the molecular bonds between these spirochetes cannot be decomposed or all of them can not be decomposed at the same time,

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Science submissionAmerican Association for the Advancement of Science,AAAS